The series revolves around a middle-aged businessman named Bob, who suffers a heart attack and falls in love with his Nigerian nurse, Abishola. Despite coming from different worlds and having different cultural backgrounds, Bob and Abishola develop a deep connection and begin a relationship. Throughout the show, they navigate the challenges of their cultural differences, family expectations, and personal struggles while dealing with humorous situations and heartwarming moments. "Bob Hearts Abishola" is a comedy-drama that explores themes of immigration, love, and family. An American guy falls in love with his Nigerian nurse.